First off, I have to say that I really like Safari's interface and overall look and functionality. The only drawback I can see at this point is that this blog has some visual issues, namely, the header graphic drops down over most of the nav bar and is situated a little off-center. The other problem is that the sidebar content is offset a bit too far to the right. Another issue is that pop-up photos (on the sites I've created) don't appear. The thumbnails are there, but the pop-up window remains blank.
These aren't horrendous problems, but some that I'm going to look into since I've had four clients that use Safari.
If any of you have some advice, I'd be more than grateful to hear from you!